The Phillips Research Group
University of Colorado, Boulder, CO 80309
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Tandem Metathesis Reactions
Inspired by the Ru-catalyzed ring-opening metathesis polymerization (ROMP) of norbornenes, we have been investigating the scope of tandem ring-opening-ring-closing-cross metathesis sequences for the synthesis of complex ring systems in the context of natural products synthesis. Our initial studies have established the viability of tandem sequences starting with norbornenes, oxanorbornenes, and bicyclo[2.2.2]octenes to provide ring systems that are of specific value to our syntheses of a number of target molecules:
