University of Colorado at Boulder
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Margaret R. Asirvatham Director of General Chemistry & Senior Instructor |
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Welcome to my chemistry web page. Chemistry is
an exciting scientific discipline and helps us to understand, appreciate,
and find solutions to many things that affect our everyday lives. For
instance, thalidomide, was introduced as a sedative in 1957 but not approved
by the FDA. Several birth defects were reported in Germany in the 1960s when
thalidomide was used to relieve morning sickness in pregnant women.
Research has shown that thalidomide affects limb development in 4-6 week
embryos. The drug is no longer used to prevent morning sickness, but is now
approved (in 1998) to treat leprosy. Thalidomide is a chiral drug and it was
shown that only one of the enantiomers had teratogenic effects. Chiral drug
synthesis is a hot research area and worldwide sales have surged to almost
$90 billion dollars.
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Comments: Contact asirvath@spot.colorado.edu Date of Creation: May 20, 2002 Date of Last Revision: May 23, 2002 |