The number of older adults in the United States is expected to double by the year 2050, resulting in a new epidemic of age-related disability and associated healthcare costs. Treatments designed to slow the progression of aging itself, are likely to be more effective at reducing the age-associated decline in physiological function than targeting individual age-related diseases. My postdoctoral research in the Integrative Physiology of Aging Laboratory is related to the identification of novel lifestyle and dietary (nutraceutical) interventions to delay or reverse the age-associated decline in physiological function, increase "healthspan", and promote healthy aging.
Kuczmarski, J.M., Martens, C.R., Kim, J., Lennon-Edwards, S., Edwards, D.G. Cardiac function is preserved following 4 Weeks of voluntary wheel running in a rodent model of chronic kidney disease. J. Appl. Physiol. 2014. Article in press.
Martens, C.R., Kuczmarski, J.M., Kim, J., Guers, J.J., Harris, M.B., Lennon-Edwards, S., Edwards, D.G. Voluntary wheel running augments aortic L-arginine transport and endothelial function in rats with chronic kidney disease. Am. J. Physiol Renal Physiol. 2014. Article in press. PubMed
Kuczmarski, J.M., Martens, C.R., Lennon-Edwards, S., Edwards, D.G. Cardiac Function and Tolerance to Ischemia-Reperfusion Injury in Chronic Kidney Disease. Neph. Dial. Transplant. 2013. Epub ahead of print. PubMed
Martens, C.R., Kuczmarski, J.M., Lennon-Edwards, S., Edwards, D.G. Impaired L-arginine uptake but not arginase contributes to endothelial dysfunction in rats with chronic kidney disease. J. Cardiovasc Pharmacol. 2014. 61(1):40-8. PubMed
Martens, C.R., Edwards, D.G. Peripheral Vascular Function in Chronic Kidney Disease. Cardiology Research & Practice. vol. 2011, article ID 267257, 9 pages, 2011. doi 10.4061/2011/267257. PubMed