Figure 15



Calcium binding site of the cPLA2 C2 domain. Two calcium ions (yellow) are bound in close proximity within the free domain. Upon membrane docking the same two calcium ions remain bound (Nalefski, Slazas & Falke, 1997; Nalefski et al., 2001). Small spheres (cyan) represent water oxygens that are presumably replaced by lipid headgroup oxygens upon membrane docking.





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