Figure 4

The eukaryotic chemotaxis pathway begins with a receptor, such as the formylated peptide receptor, which upon activation sends a signal that generates PIP3 at the leading edge of the cell. PIP3 and Ca2+ ions localized at the leading edge are essential components of a positive feedback loop that maintains leading edge structure and activity. These PIP3 and Ca2+ signals recruit PH and C2 domains proteins to the leading edge membrane, where they stimulate actin polymerization that pushes the leading edge up the attractant gradient.

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