Education

· BA/MS in Integrative Physiology, University of Colorado at Boulder, May 2011

· Minor in Italian

 

Research Interests

Role of mitochondria-derived oxidative stress in age-related vascular dysfunction; therapeutic potential of mitochondrial-targeted antioxidants and other strategies to reduce mitochondria-derived oxidative stress for the amelioration of age-related vascular dysfunction.

 

Research and Teaching Experience

· June 2011-present: Graduate Research Assistant, Integrative Physiology of Aging Laboratory

 

· August 2009-Dec 2011: Graduate Teaching Assistant, Department of Integrative Physiology

                 Courses:

                   IPHY 2800 (Introduction to Statistics/Research in IPHY)

                   IPHY 3415 (Human Physiology Laboratory)

                   IPHY 4540 (Biomechanics)

                   IPHY 3060 (Cellular Physiology Laboratory)

 

· May 2009-May 2011: Master’s Student, Cardiac Physiology Laboratory (Dr. Russell L. Moore), University of Colorado at Boulder

 

· June 2006-April 2009: Undergraduate Research Assistant, Cardiac Physiology Laboratory

 

Publications

Edwards AG, Donato AJ, Lesniewski LA, Gioscia RA, Seals DR, Moore RL. Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK. Mech Ageing Dev.  2010. 131:739-742.

 

Edwards AG, Rees ML, Gioscia RA, Zachman DK, Lynch JM, Browder JC, Chicco AJ, Moore RL. PKC-permitted elevation of sarcolemmal K_ATP concentration may explain female-specific resistance to myocardial infarction. J Physiol. 2009. 587.23:5723-5737.

 

Abstracts

Gioscia-Ryan RA, Zigler MC, Seals DR, Sindler AL, LaRocca TJ. Polyamine supplementation reduces oxidative stress and reverses vascular endothelial dysfunction with aging. Experimental Biology 2012, San Diego, CA.

 

LaRocca TJ, Gioscia-Ryan RA, Fleenor BS, Seals DR. Polyamine supplementation enhances autophagy and reverses age-related arterial stiffening. Experimental Biology 2012, San Diego, CA.

 

Hearon Jr., CM, Gioscia-Ryan RA, Seals DR, LaRocca TJ. Mitochondria-targeted antioxidant therapy reduces age-related arterial stiffness. Experimental Biology 2012, San Diego, CA.

 

Justice JN, Chettat S, Gioscia-Ryan RA, Seals DR, Enoka RM. Mouse model of age-related reductions in motor function. International Academy on Nutrition and Aging (IANA, abstract and poster), 2012.

 

Laboratory Skills

Western blotting, QRT-PCR, lipid extraction, cardiac mitochondrial isolation, animal care, enzyme activity assays (spectrophotometry), isolated mitochondrial respiration, cell culture, ex vivo vessel function (pressure myograph), tail cuff blood pressure, mouse aortic pulse wave velocity.

 

Honors and Memberships

· Phi Beta Kappa, member 2009-present

· Big 12 Conference Prentice Gautt Postgraduate Fellowship, 2009

· American College of Sports Medicine student member, 2010-2011

· Dept. Of Integrative Physiology Highest GPA award, May 2011

· American Physiological Society graduate student member, Jan 2012-present

· University of Colorado Integrative Physiology of Aging Training Grant (T32), May 2012-May 2013

 

Interests and Activities

Competitive running (track, road, cross-country) in distances ranging from 1500m to 10,000m:

 

· Member of Boulder Running Company/adidas Retail Race Team

 

· Intercollegiate Division I Cross-Country and Track, 2005-2009, University of Colorado