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MCDB 4444 © 1999-2001 M.W. Klymkowsky |
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INSTRUCTOR:
Mike Klymkowsky|
Next offered - Fall 2004 by Gretchen Stein web resources | texts | contact |
| The Cell - its history and a review of terms |
| Where diseases come from |
| Diseases of intrinsic factors |
| Superoxide dismutase & neurogenerative disease |
| Hypersensitivity, allergy and autoimmunity: Grave's disease & Hasimoto's thyroiditis |
| Pregnancy, immunity, cancer |
| Cancer 2 | Cancer 3 |
| Diseases of protein folding/degradation |
| Diseases of protein processing: Alzheimer's disease |
| Diseases of intracellular targeting and evolution |
| Diseases of intracellular targeting |
| Diseases of DNA replication : Triplet repeat diseases |
| Cytoskeletal diseases part 1 | part 2 |
| Student presentations |
| Factor
V Leiden Disorder HIV/AIDS/CD4 |
| Thalassemia
Adenosine Deaminase Deficiency |
| Obesity
Insulin-dependent Diabetes Mellitus Placebo Effects |
| Adrenoleukodystrophy
Infantile Krabbe Disease |
| Neurofibromatosis,
type I Folate deficiency |
| Peutz-Jeghers
Syndrome Rheumatoid Arthritis Influenza & oxidative stress |
| Hodgkin's
Lymphoma TB & drug resistance Cystic Fibrosis |
| Hypertrophic
cardiomyopathy Grave's Disease & Hyperthyroidism Bloom's syndrome |
| Type
II Diabetes Von-Hippel-Lindau Syndrome Immune system and wound healing. |
| Type
II Diabetes Spinal Muscular Atrophy |
| Familial
Combined Hyperlipidaemia Degenerative Disc Disease |
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Course
Description:
The class will explore the cellular basis of disease and healing.
Diseases arising from defects in intracellular targeting, cytoskeletal
function, intracellular signaling, genomic instability, gene regulation,
cell proliferation and cell death will be discussed. The course
involves student driven literature/web research, organized classroom presentations
and discussion, and a final research paper.
Prerequisites:MCDB 2150 (Genetics), MCDB 3100 (Cell Biology)or MCDB 3500 (Molecular Biology). Books: Although there is no perfect book for what we will be covering, I strongly suggest that you buy Mechanisms of Disease by Tomlinson et al (1997) as a good background references. It may take a few weeks to arrive, however. (Here is a link to other "on-line" bookstores that you could check as well). You may want to have your old Cell Biology/Molecular Biology textbook to refresh yourself on specific ideas when necessary. Access to Basic Histology and Pathology texts could be helpful in some cases, although I do not think that these are really necessary (and they are somewhat pricey). Organization: The first half (roughly) of the course will be focussed on lectures and class room discussion of selected papers. In the second half, each student will pick a disease, research its symptoms, molecular causes, genetic modifiers, and consider various approaches to prevention/cure and their possible complications. Each student will be expected to present their work in the classroom (roughly 20-25 min. presentation) and then prepare a research paper (roughly 20 pages in length) summarizing their work. As an alterantive, the final project can be a web site (that includes the material that would have been in a paper). During the after the second week, students will submit a short discription of their proposed topic for approval and discussion. The goal is to pick a disease with more than one or two references related to it. Grading:
There will be a midterm exam on the first part of the course (lecture/discussions).
You
are free to use any material for non-commerical purposes
Go back to the Klymkowsky Lab home page last modified - 12 march 2001 |