Dhinakar S. Kompala Associate Professor Chemical & Biological Engineering Department University of Colorado Boulder, CO 80309-0424

(303) 492-6350 phone (303) 492-4341 fax kompala@colorado.edu spot.colorado.edu/~kompala

Education:

B.Tech. Indian Institute of Technology, Madras (1979)

M.S., Ph.D. Purdue University (1982, 1984)

NSF Presidential Young Investigator Award (1988)

R.H. Davis, C.-Y. Lee, B.C. Batt and D.S. Kompala, "Cell Separation Using Differential Sedimentation in Inclined Settlers," in Cell Separation Science and Technology, eds.: D.S. Kompala and P.W. Todd, ACS Symposium Series, vol. 464, 113-127 (1991).

M.B. Gu, J.A. Kern, P.W. Todd, and D.S. Kompala, "Effect of Amplification of dhfr and lac Z Genes on Growth and β-galactosidase Expression in Suspension Cultures of Recombinant CHO Cells," Cytotechnology, 9, 237-245 (1992).

F. Miao, and D.S. Kompala, "Overexpression of Cloned Genes Using Recombinant E. coli Regulated by T7 Promoter. II Two-stage Continuous Cultures and Model Situations," Biotechnology and Bioengineering, 42, 74-80 (1993).

J.G. Highfill, , S. Haley, and D.S. Kompala, "Large-scale Production of Murine Bone Marrow Cells in an Airlift Packed Bed Bioreactor," Biotechnology and Bioengineering, 50, 514-520 (1996).

Recombinant Mammalian Cell Cultures

Metabolic Pathway Engineering

Tissue Engineering

Bioprocess Engineering:

This course is offered jointly to undergraduate ChE seniors following the biotechnology/pre-medicine curriculum option and to entering graduate students interested in biotechnology research. In addition to the classroom lectures, homework assignments (click here for sample) and tests (click here for sample), a major component of the course involves four hands-on laboratory exercises

1. Enzyme Kinetics
2. Yeast Fermentation
3. Recombinant Bacterial Growth and Foreign Protein Production
4. Perfusion Cultures of CHO Cells