Dhinakar S. Kompala
Publications

Refereed Publications

  1. Ramkrishna, D., D.S. Kompala and G.T. Tsao, "Cybernetic modeling of microbial populations. Growth on mixed substrates," Proceedings of the International Chemical Reaction Engineering Conference, Pune, India, Vol. 1, 241-260, Wiley Eastern Ltd. (1984).
  2. Kompala, D.S., D. Ramkrishna and G.T. Tsao, "Cybernetic modeling of microbial growth on multiple substrates," Biotechnology and Bioengineering 26:1272-1281 (1984).
  3. Kompala, D.S., D. Ramkrishna, N.B. Jansen and G.T. Tsao, "Investigation of bacterial growth on mixed substrates. Experimental evaluation of cybernetic models," Biotechnology and Bioengineering 28:1044-1055 (1986).
  4. Bentley, W.E. and D.S. Kompala, "A novel structured kinetic modeling approach for analysis of plasmid instability in recombinant bacterial fermentations," Biotechnology and Bioengineering 33:49-61 (1989).
  5. Bentley, W.E. and D.S. Kompala, "Using structured kinetic model for analyzing instability in recombinant bacterial cultures," in Frontiers in Bioprocessing, Eds: S.K. Sikdar, M. Bier and P.W. Todd, CRC Books, pp. 129 - 138, (1989.)
  6. Batt, B.C. and D.S. Kompala, "Structured kinetic modeling of hybridoma growth and monoclonal antibody production in suspension cultures," Biotechnology and Bioengineering 34:515-531 (1989).
  7. Davis, R.H. and D.S. Kompala, "Biotechnology laboratory methods," Chemical Engineering Education 22:182-187 (1989).
  8. Batt, B.C. and D.S. Kompala, "Verification of immune response optimality through cybernetic modeling," Journal of Theoretical Biology 142:317-340 (1990).
  9. Bentley, W.E. and D.S. Kompala, "Optimal induction of foreign protein expression in recombinant bacterial cultures," Annals of New York Academy of Sciences "Biochemical Engineering VI" 589: 121-138 (1990).
  10. Bentley, W.E., N. Mirjalili, P.C. Andersen, R.H. Davis and D.S. Kompala, "Plasmid-encoded protein: the principal factor in the metabolic burden associated with recombinant bacteria," Biotechnology and Bioengineering 35:668-681 (1990).
  11. Bentley, W.E. and D.S. Kompala, "Plasmid instability in batch cultures of recombinant bacteria," Chemical Engineering Education 24:168-172 (1990).
  12. Bentley, W.E. and D.S. Kompala, "Continuous culture dynamics of recombinant bacterial fermentations," Biotechnology Letters 12:329-334 (1990).
  13. Batt, B.C., R.H. Davis, and D.S. Kompala, "Inclined sedimentation for enhancing viable hybridoma concentrations in continuous suspension bioreactors," Biotechnology Progress 6:458-464 (1990).
  14. Bentley, W.E., R.H. Davis, and D.S. Kompala, "Dynamics of induced CAT expression in batch cultures of E. coli [pKK262-1]," Biotechnology and Bioengineering 38:749-760 (1991).
  15. Davis, R.H., C.-Y. Lee, B.C. Batt and D.S. Kompala, "Cell separation using differential sedimentation in inclined settlers," in Cell Separations Science and Technology. Eds: D.S. Kompala and P.W. Todd, ACS Symposium Series, vol. 464: 113-127 (1991).
  16. Miao, F., and D.S. Kompala, "Optimization of continuous two-stage fermentations of recombinant bacteria: modeling and experimental analyses," Annals of N.Y. Acad. Sci. "Recombinant DNA Technology I"646: p. 273-283 (1991).
  17. Miao, F., and D.S. Kompala, "Analysis of two-stage recombinant bacterial fermentations using a structured kinetic model," Bioprocess Engineering 7:249-255 (1992).
  18. Gu, M.B., J.A. Kern, P.W. Todd, and D.S. Kompala, "Effect of amplification of dhfr and lac Z genes on growth and -galactosidase expression in suspension cultures of recombinant CHO cells", Cytotechnology 9:237-245 (1992).
  19. Miao, F., and D.S. Kompala, "Overexpression of cloned genes using of recombinant E. coli regulated by T7 promoter I. Batch cultures and kinetic modeling," Biotechnology and Bioengineering 40: 787-796 (1992).
  20. Miao, F., and D.S. Kompala, "Overexpression of cloned genes using of recombinant E. coli regulated by T7 promoter. II Two-stage continuous cultures and model simulations," Biotechnology and Bioengineering 42: 74-80 (1993).
  21. Miao, F., and D.S. Kompala, "Characterizations of gene expression in recombinant Escherichia coli cells infected with phage" Biotechnology Progress 9:153-159 (1993).
  22. Miao, F., P.W. Todd, and D.S. Kompala, "A single-cell assay of -galactosidase in recombinant Escherichia coli using flow cytometry" Biotechnology and Bioengineering 42: 708-715 (1993).
  23. Gu, M.B., P.W. Todd, and D.S. Kompala, "Foreign gene expression (-galactosidase) during cell cycle phases in recombinant CHO cells," Biotechnology and Bioengineering 42:1113-1123 (1993).
  24. Gu, M.B., P.W. Todd, and D.S. Kompala, "Analysis of foreign protein overproduction in recombinant CHO cells: effect of growth kinetics and cell cycle traverse" Annals of N.Y. Acad. Sci. "Recombinant DNA Technology II" vol. 721:194-207 (1994).
  25. Searles, J.A., P.W. Todd, and D.S. Kompala, "Viable cell recycle with an inclined settler in the perfusion culture of suspended recombinant CHO cells", Biotechnology Progress 10:198-206(1994).
  26. Gu, M.B., P.W. Todd, and D. S. Kompala, "Cell cycle analysis of foreign gene (-galactosidase) expression in recombinant mouse cells under the control of the mouse mammary tumor virus promoter", Biotechnology and Bioengineering 50: 229-237 (1996).
  27. Gu, M.B., P.W. Todd, and D. S. Kompala, "Metabolic burden in recombinant CHO cells: Effect of dhfr gene amplification and lacZ expression" Cytotechnology 18: 159-166 (1996).
  28. Gu, M.B., P.W. Todd, and D. S. Kompala, "Growth and induction kinetics of inducible expression of heterologous protein in recombinant mouse L cell lines" Biotechnology Progress 12: 226-233 (1996).
  29. Gu, M.B., P.W. Todd, and D.S. Kompala, "Large-scale produce of murine bone marrow-cells in an airlift packed bed bioreactor," Biotechnology and Bioengineering 50: 516-520 (1996).
  30. Jones, K.D., and D.S. Kompala, "Cybernetic modeling of sustained metabolic oscillations in yeast continuous cultures," (submitted).
  31. Ramkrishna, D., D.S. Kompala, and G.T. Tsao, "Are microbes optimal strategists?" Biotechnology Progress 3:121-126 (1987).
  32. Highfill, J.G., S. Haley, and D.S. Kompala, "Tissue culture scale expansion of murine bone marrow cells - effects of inoculum density and conditioned medium," (submitted).

Book Edited

  1. Kompala, D.S., and P.W. Todd, Cell Separation Science and Technology, American Chemical Society Symposium Series, vol. 464, 1991, Washington, DC.

Other Publications

  1. Bentley, W.E. and D.S. Kompala, "Modeling the effects of plasmid replication and protein overexpression on the growth rate of recombinant bacteria," Proceedings of 16th Annual Biochemical Engineering Symposium, Eds.: L.E. Erickson, and L.T. Fan, Kansas State University, p. 41-49, 1986.
  2. Batt, B.C. and D.S. Kompala, "Structured kinetic modeling of hybridoma growth and monoclonal antibody production in suspension cultures," Proceedings of 17th Annual Biochemical Engineering Symposium, Ed.: P.J. Reilly, Iowa State University p. 77-86, 1987.
  3. Bynum, M.T., D.S. Kompala, K. Grohmann and C.E. Wyman, "Modeling of Brettanomyces clausenii growth on mixtures of glucose and cellobiose," Proceedings of 17th Annual Biochemical Engineering Symposium, Ed.: P.J. Reilly, Iowa State University, p. 97-106, 1987.
  4. Bentley, W.E. and D.S. Kompala, "Using structured kinetic model for analyzing instability in recombinant bacterial cultures," Proceedings of 17th Annual Biochemical Engineering Symposium, Ed.: P.J. Reilly, Iowa State University, p. 145-154, 1987.
  5. Bentley, W.E., D.C. Andersen, D.S. Kompala, and R.H. Davis, "Metabolic Effects of chloramphenicol resistance in the recombinant host/vector system: E. coli RRI [pBR329]," Proceedings of 18th Annual Biochemical Engineering Symposium, Ed.: R.H. Davis, University of Colorado, p. 77-84, 1988.
  6. Miao, F. and D.S. Kompala, "Analysis of two-stage recombinant bacterial fermentations using a structured kinetic model," Proceedings of 19th Annual Biochemical Engineering Symposium, Ed: R.K. Bajpai, Univ. of Missouri, Columbia, p. 47-56, 1989.
  7. Bentley, W.E. and D.S. Kompala, "Plasmid instability in batch cultures of recombinant bacteria: a laboratory experiment," Proceedings of 1989 ASEE Annual Conference, p. 996-998, 1989.
  8. Kern, J.A. and D.S. Kompala, "Overexpression in recombinant mammalian cells: Effect on growth rate and genetic instability." Proceedings of 20th Annual Biochemical Engineering Conference. Ed.: L.E. Erickson, Kansas State University, 1990.
  9. Vant-Hull, B. and D.S. Kompala, "Dynamics of modeling of the immune system," Proceedings of 20th Annual Biochemical Engineering Conference, p. 31-40, Ed.: L.E. Erickson, Kansas State University, 1990.
  10. Kompala, D.S., "Inclined sedimentation for enhancing the productivity of recombinant mammalian cells in perfused suspension bioreactors", in Biotechnology in the 21st Century, Ed.: C. Ayyanna, Tata McGraw-Hill, New Delhi, India, p. 69-85, 1993.
  11. Miao, F., and D.S. Kompala, "Characterization of foreign gene expression in a recombinant T7 expression system". Proceedings of 21st Annual Biochemical Engineering Conference, Ed.: P.J. Reilly, Iowa State University, p. 31-38, 1992.
  12. Highfill, J.G., P.W. Todd, and D.S. Kompala, "A culture system for murine bone marrow cells", Proceedings of 23rd Annual Biochemical Engineering Conference, Ed.: R. Harrison, p.17-25. Oklahoma State University, 1993.
  13. Jones, K.D., and D.S. Kompala, "Cybernetic modeling of sustained oscillations in continuous cultures of Saccharouryces cerevisiare", Proceedings of 24th Annual Biochemical Engineering Conference, Ed.: R.H. Davis, University of Colorado p. 50-58, 1994.
  14. Searles, J.A., P.W. Todd, and D.S. Kompala, "Perfusion culture of suspended CHO cells employing inclined sedimentation," in Animal Cell Technology, Eds.: R.E. Spier, J.B. Griffiths, and W. Berthold, p. 240-242, Proceedings of the 12th Meeting of European Society for Animal Cell Technology, Butterworth-Heinemann Ltd., Oxford, 1994.
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Prof. Dhinakar S. Kompala / Department of Chemical Engineering
College of Engineering / University of Colorado