Current Research Interests
Mechanisms of decreased endothelium dependent dilation and increased inflammation and oxidative stress during aging
Molecular Mechanisms Associated with Cardiovascular Aging: Modulatory Influence of Regular Aerobic Exercise
Concurrent B.A. and M.S. in Integrative Physiology
University of Colorado, Boulder, 2009
Integrative Physiology of Aging Laboratory, Professional Research Assistant
Integrative Physiology of Aging Laboratory, Graduate Assistant
Human Integrative Physiology Laboratory, Undergraduate Assistant
Graduate Teaching Assistant, Fall 2008 and Spring 2009: Exercise Physiology Lab
Undergraduate Teaching Assistant, Spring 2008: Exercise Physiology Lab
Subject screening and testing
Physiological Testing Experience
Graded Exercise Tests
VO2 Max Testing
Flow Mediated Dilation
Venous Occlusion Plethysmography
In Vitro Isolated Vessel Vascular Reactivity
Wetlab Experience (Molecular and Cellular)
Endothelial Cell Collection and Processing
Mononuclear Cell Isolation
Ex-Vivo Whole Blood Cytokine Production
Durrant, J., Seals, D., Connell, M., Russell, M., Lawson, B., Folian, B., Donato, A., & Lesniweski, L. (2009). Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. J Physiol. Volume 587.13, pages 3271-3285.
o Perspective written on above manuscript:
Lombard, J. (2009). Reduced oxidant stress, increased NO-dependent vasodilatation, and improved endothelial function with voluntary exercise in old mice: another excuse for long walks on the beach. J Physiol. Volume 587.13, page 3059.
Walker AE, Pierce GL, Kaplon RE, Russell MJ, Lesniewski LA, Donato AJ, Seals DR. Absence of nuclear factor κB-mediated suppression of vascular endothelial function with aging in exercising adults. FASEB J, Apr 2011; 25: 821.6.
Connell ML, Durrant JR, Russell MJ, Donato AJ, Seals DR and Lesniewski LA. Voluntary wheel running abolishes vascular inflammation and restores endothelial function in old mice. FASEB J, Apr 2009; 23: 777.6.
Russell MJ, Folian BJ, Durrant JR, Connell ML, Seals DR and Lesniewski LA. Aging increases susceptibility to western diet-induced glucose intolerance and insulin resistance in mice. FASEB J, Apr 2009; 23: 990.18.
Connell ML, Durrant JR, Folian BJ, Russell MJ, Seals DR and Lesniewski LA. Anti-inflammatory treatment restores endothelium-dependent dilation in older mice by increasing nitric oxide bioavailability. FASEB J. Mar 2008; 22: 967.5.
Durrant JR, Connell ML, Folian BJ, Russell MJ, Seals DR and Lesniewski LA. B6D2F1 mouse model to study the effects of habitual aerobic exercise on vascular endothelial dysfunction with aging. FASEB J. Mar 2008; 22: 1235.11.