Amy L. Sindler, Ph.D.
Department of Integrative Physiology
201 Carlson, 354 UCB
University of Colorado
Boulder, CO 80309-0354, USA
Phone: (303) 492-3010
Fax: (303) 492-6778
á Determining the mechanisms by which aging and age-related diseases impair vascular function
á Nitrite supplementation as an anti-aging therapy
Ph.D., Cellular and Integrative Physiology, West Virginia University, Morgantown, WV, 2009
M.S., Exercise Physiology, West Virginia University, Morgantown, WV 2003
B.S., Exercise Physiology, West Virginia University, Morgantown, WV 2001
Sindler AL, Gurovich AL, Reyes R, Chen B, Delp MD, Kang LS, Cardounel AJ, Muller-Delp. Age and exercise training alter signaling through reactive oxygen species in the endothelium of skeletal muscle arterioles. Journal of Applied Physiology, in revision.
Sindler AL, Fleenor BS, DeVan AE, Seals DR. Sodium nitrite in the treatment of arterial aging. Journal of Applied Physiology, in review.
Fleenor BS, Sindler AL, Marvi NK, Howell KL, Zigler ML, Yoshizawa M, Seals DR. Curcumin Ameliorates Arterial Dysfunction and Oxidative Stress with Aging. Experimental Gerontology, in revision.
Sasser JM, Akinsiku O, Moningka NC, Jerzewski K, Baylis C, Leblanc AJ, Kang LS, Sindler AL, Muller-Delp JM. Sexual dimorphism in development of kidney damage in aging Fischer-344 rats. Gend Med. 2012 Aug;9(4):219-31.
Fleenor BS, Sindler AL, Eng JS, Nair DP, Dodson RB, Seals DR. Sodium nitrite de-stiffening of large elastic arteries with aging is associated with normalization of advanced glycation end-products. Exp Gerontol. 2012 Aug;47(8):588-94.
LaRocca, TJ, Henson GD, Thorburn A, Sindler AL, Pierce GL, Seals DR. Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol. 2012 Jul 15;590(Pt 14):3305-16.
Fleenor BS, Seals DR, Zigler ML, Sindler AL. Superoxide–lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice. Aging Cell. 2012 Apr;11(2):269-76.
Moningka NC, Sindler AL, Muller-Delp JM, Baylis. Twelve weeks of treadmill exercise does not reverse age-dependent chronic kidney disease in the Fisher 344 male rat. J Physiol. 2011 Dec 15;589(Pt 24):6129-38.
Sindler AL, Fleenor BS, Calvert JW, Marshall KD, Zigler ML, Lefer DJ, Seals DR. Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging. Aging Cell. 2011 Jun;10(3):429-37.
Calvert JW, Elston M, Aragon JP, Nicholson CK, Moody BF, Hood RL, Sindler AL, Gundewar S, Seals DR, Barouch LA, Lefer DJ. Exercise Protects the Heart Against Myocardial Ischemia-Reperfusion injury via stimulation of β3-Adrenergic Receptors and Increased Cardiac Storage of Nitrite and Nitrosothiols. Circ Res. 2011 Jun 10;108(12):1448-58
Sindler AL, Delp MD, Reyes R, Wu G, Muller-Delp JM. Effects of aging and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles. J Physiol 587: 3885-97, 2009
Kang LS, Kim SJ, Dominguez JM 2nd, Sindler AL, Dick GM, Muller-Delp JM. Aging and muscle fiber type alter K+ channel contributions to the myogenic response in skeletal muscle arterioles. J Appl Physiol 107 (2): 389-98, 2009
Peterson JM, Bryner RW, Sindler A, Frisbee JC, Alway SE. Mitochondrial apoptotic signaling is elevated in cardiac but not skeletal muscle in the obese Zucker rat and is reduced with aerobic exercise. J Appl Physiol, 105: 1934-43, 2008
Spranger J, Verma S, Ghring I, Bobbert T, Seifert J, Sindler AL, Pfeiffer A, Hileman SM, Tschp M, Banks WA. Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes, 55: 141-47, 2006
LaRocca TJ, Henson GD, Sindler AL, Seals DR. Impaired mitochondrial quality control contributes to arterial aging. Keystone Symposium on Mitochondrial Dynamics and Function
Yoshizawa M, Seals DR, Zigler ML, Ahsan S, Sindler AL. Role of superoxide in cerebrovascular endothelial dysfunction with aging. FASEB J March 29, 2012 26:lb652
Eng JS, Sindler AL, Seals DR, Fleenor BS. Advanced glycation end-products in age-related arterial stiffening: modulation by sodium nitrite. FASEB J March 29, 2012 26:lb655
Gioscia-Ryan RA, Zigler MC, Seals DR, Sindler AL, LaRocca TJ. Polyamine supplementation reduces oxidative stress and reverses vascular endothelial dysfunction with aging. FASEB J March 29, 2012 26:865.4
Sindler AL, Zigler MC, Yoshizawa M, Baylis C, Seals DR. Sodium nitrite treatment restores vascular endothelial function in old mice with CKD. FASEB J March 29, 2012 26:865.17
Sasser J, Akinsiku O, Moningka N, Jezewski K, LeBlanc A, Kang L, Sindler A, Muller-Delp J, Baylis C. No sexual dimorphism in development of kidney damage in the aging Fischer-344 (F344) rat kidney. Submitted to APS Conference on Gender Disparities in Physiology of Cardiovascular Disease, Oct 2011.
Sindler AL, Howell KL, Zigler ML, LaRocca TJ, Fleenor BS, Calvert JW, Lefer DJ, Seals DR. Nitrite supplementation improves age-associated vascular endothelial function and arterial markers of mitochondrial function. Nitric Oxide Volume 24, Supplement 1, May 2011, Page S40
Sindler AL, Marvi NK, Claassen N, Calvert JW, Lefer DJ, Seals DR. Nitrite supplementation reverses large elastic artery stiffening with aging: potential role of arterial advanced glycation end-products. Nitric Oxide Volume 24, Supplement 1, May 2011, Page S27
Sindler AL, Fleenor BS, Zigler ML, Marshall KD, Howell KL, Seals DR. Superoxide-lowering therapy with TEMPOL reverses age-associated large elastic artery stiffening and endothelial dysfunction in mice. FASEB J March 17, 2011 25:821.10
Howell, KL, Fleenor BS, Zigler ML, Yoshizawa M, Marziaz M, Seals DR, Sindler AL. Curcumin improves large elastic artery stiffness and reverses superoxide suppression of nitric oxide-mediated vascular endothelial function in old mice. FASEB J March 17, 2011 25:lb453
Fleenor BS, Sindler AL, Marvi NK, Claassen N, Calvert JW, Lefer DL, Seals DR. Sodium nitrite treatment de-stiffens large elastic arteries in old mice: modulation of advanced glycation end-products. FASEB J March 17, 2011 25:641.9
Fleenor BS, Sindler AL, Marshall KD, Sneider H, Marvi N, Esheverria C, Seals DR. Direct evidence for superoxide signaling in large elastic artery stiffening with aging in mice. FASEB J March 17, 2011 25:821.33
Henson GD, LaRocca TJ, Sindler AL, Fleenor BS, Seals DR. Autophagy-enhancing treatment reverses age-associated large elastic artery stiffening and modulates arterial superoxide production, inflammation and collagen I. FASEB J March 17, 2011 25:lb466
LaRocca TJ, Henson GD, Sindler AL, Seals DR. Autophagy-enhancing therapy reduces oxidative stress and restores vascular endothelial function in old mice. FASEB J March 17, 2011 25:lb452
Sindler AL, Calver JW, Fleenor BS, Zigler ML, Lefer DJ, Seals DR. Nitrite supplementation reverses vascular endothelial dysfunction in old mice via improved nitric oxide bioavailability FASEB J. 2010 24:1039.6
Calvert JW, Elston M, Sindler AL, Gundewar S, Grinsfelder DB, Aragon JP, Seals DR, Lefer DJ. The Generation and Storage of Nitric Oxide Metabolites During Exercise Training Contributes to Exercise-Mediated Cardioprotection J. Am. Coll. Cardiol.2010;55;A116.E1081
Moningka NC, Sindler AL, Muller-Delp J, Baylis C. Twelve Weeks of Treadmill Exercise Accelerates Age-Dependent Kidney Disease in the Fisher 344 (F344) Male Rat. J Am Soc Nephrol 20: 2009 SA-PO2229
Sindler AL, Delp MD, Reyes R, Wu G, Muller-Delp JM. Effect of aging and exercise training on eNOS uncoupling and O2- signaling in skeletal muscle arterioles. FASEB J. 2009 23:608.12.
Sindler AL, Reyes R, Muller-Delp J. Oxidant Stress is Required for Endothelium-Dependent Dilation in Skeletal Muscle Arterioles. The Physiologist Dec 2008 51:p 38.
Morgan SM, Kang LS, Sindler AL, Kim SJ, Muller-Delp JM. Voltage-gated Potassium Channel Regulation of Myogenic Activity Increases with Age in Soleus Muscle Arterioles. Microcirculation Jun 2007, 14; Issue 4/5, p547, VR-44.
Sindler AL, Kang LS, Dominguez J, Reyes R, Muller-Delp, JM. Effects of Tempol on Endothelial-Dependent Vasodilation in Soleus Muscle Arterioles in Response to Age and
Exercise Training. FASEB J 2007, 21:lb462
Sindler AL, Morgan SM, Reyes R, Peterson J, Frisbee J, Muller-Delp JM, Bryner R, Hileman SM. Chronic Exercise Training Increases Insulin Sensitivity in Obese Zucker Rats Potentially Via Hypothalamic Adiponectin Receptor 1. Medicine and Science in Sports and Exercise 2006. 38(11): p. Suppl 1: S39.
R21-HL107105; NIH/NHLBI; 7/2011-6/2013; Clinical Translation of Nitrite Therapy to Treat Arterial Aging in Humans; Co-Investigator (Seals, PI)
NIH/Intervention Testing Program; ŇSodium nitrite to increase longevity in miceÓ
Co-PI: Sindler, AL (PI: Seals, DR) Agency: National Institute on Aging
University of Colorado Denver Aging Training Grant (T32) recipient. Role of Dietary Nitrite Supplementation on Reversing Arterial Aging. 5/01/10-5/01/12
APS Cardiovascular Section Research Recognition Award, 2011.
Approaching the Clinic: Nitrite and Nitrate Pathophysiology and Therapy Conference Presentation Award, 2011.