Amy L. Sindler, Ph.D.
Research Associate
Department of Integrative Physiology
Integrative Physiology
of Aging Laboratory
201 Carlson, 354 UCB
University of Colorado
Boulder, CO 80309-0354, USA
Phone: (303)
492-3010
Fax: (303) 492-6778
email: amy.sindler@colorado.edu
Research Interests
á Determining the mechanisms
by which aging and age-related diseases impair vascular function
á Nitrite supplementation as
an anti-aging therapy
Education
Ph.D., Cellular and Integrative Physiology, West Virginia University, Morgantown, WV, 2009
M.S., Exercise Physiology, West Virginia University,
Morgantown, WV 2003
B.S., Exercise Physiology,
West Virginia University, Morgantown, WV 2001
Full-Length Manuscripts
Sindler AL, Gurovich AL, Reyes R, Chen B, Delp MD, Kang LS, Cardounel AJ,
Muller-Delp.
Age and exercise training alter signaling through reactive oxygen
species in the endothelium of skeletal muscle arterioles. Journal of Applied
Physiology, in revision.
Sindler AL, Fleenor BS, DeVan AE, Seals
DR. Sodium
nitrite in the treatment of arterial aging. Journal of Applied
Physiology, in review.
Fleenor BS, Sindler AL, Marvi
NK, Howell KL, Zigler ML, Yoshizawa
M, Seals DR. Curcumin Ameliorates
Arterial Dysfunction and Oxidative Stress with Aging. Experimental
Gerontology, in revision.
Sasser JM, Akinsiku
O, Moningka NC, Jerzewski
K, Baylis C, Leblanc AJ, Kang LS, Sindler AL, Muller-Delp
JM. Sexual
dimorphism in development of kidney damage in aging Fischer-344 rats. Gend Med. 2012 Aug;9(4):219-31.
Fleenor BS, Sindler AL, Eng
JS, Nair DP, Dodson RB, Seals DR.
Sodium nitrite de-stiffening of large elastic arteries with aging is
associated with normalization of advanced glycation end-products.
Exp Gerontol. 2012 Aug;47(8):588-94.
LaRocca, TJ, Henson GD, Thorburn
A, Sindler AL, Pierce GL, Seals DR.
Translational evidence that impaired autophagy contributes to arterial
ageing. J Physiol. 2012 Jul 15;590(Pt
14):3305-16.
Fleenor BS, Seals DR, Zigler ML, Sindler
AL. Superoxide–lowering
therapy with TEMPOL reverses arterial dysfunction with aging in mice. Aging
Cell. 2012 Apr;11(2):269-76.
Moningka NC, Sindler AL, Muller-Delp JM, Baylis.
Twelve weeks of treadmill exercise does not reverse age-dependent
chronic kidney disease in the Fisher 344 male rat. J Physiol. 2011 Dec
15;589(Pt 24):6129-38.
Sindler AL, Fleenor BS, Calvert JW, Marshall KD, Zigler ML, Lefer DJ, Seals
DR. Nitrite supplementation
reverses vascular endothelial dysfunction and large elastic artery stiffness
with aging. Aging Cell. 2011 Jun;10(3):429-37.
Calvert JW, Elston
M, Aragon JP, Nicholson CK, Moody BF, Hood RL, Sindler AL, Gundewar S, Seals DR, Barouch LA,
Lefer DJ. Exercise Protects the Heart Against
Myocardial Ischemia-Reperfusion injury via stimulation of β3-Adrenergic
Receptors and Increased Cardiac Storage of Nitrite and Nitrosothiols.
Circ Res. 2011 Jun 10;108(12):1448-58
Sindler AL, Delp MD,
Reyes R, Wu G, Muller-Delp JM. Effects
of aging and exercise training on eNOS uncoupling in skeletal muscle resistance
arterioles. J Physiol
587: 3885-97, 2009
Kang LS, Kim SJ,
Dominguez JM 2nd, Sindler AL, Dick GM, Muller-Delp
JM.
Aging and muscle fiber type alter K+ channel contributions to the myogenic
response in skeletal muscle arterioles. J Appl Physiol 107 (2): 389-98, 2009
Peterson JM, Bryner
RW, Sindler A, Frisbee JC, Alway SE.
Mitochondrial apoptotic signaling is elevated in cardiac but not skeletal
muscle in the obese Zucker rat and is reduced with
aerobic exercise. J Appl Physiol, 105: 1934-43, 2008
Spranger J, Verma S, Gšhring I, Bobbert T, Seifert J, Sindler AL, Pfeiffer A, Hileman SM, Tschšp M, Banks
WA. Adiponectin does not cross the
blood-brain barrier but modifies cytokine expression of brain endothelial
cells. Diabetes, 55: 141-47, 2006
Recent Abstracts
LaRocca TJ, Henson GD, Sindler AL,
Seals DR. Impaired mitochondrial
quality control contributes to arterial aging. Keystone Symposium on Mitochondrial
Dynamics and Function
Yoshizawa M, Seals DR, Zigler
ML, Ahsan S, Sindler AL. Role of superoxide in
cerebrovascular endothelial dysfunction with aging. FASEB J March 29, 2012 26:lb652
Eng JS, Sindler AL, Seals DR,
Fleenor BS. Advanced glycation end-products in age-related arterial stiffening: modulation
by sodium nitrite. FASEB J
March 29, 2012 26:lb655
Gioscia-Ryan RA, Zigler MC, Seals DR, Sindler AL, LaRocca
TJ. Polyamine supplementation reduces oxidative
stress and reverses vascular endothelial dysfunction with aging. FASEB J March 29, 2012 26:865.4
Sindler AL, Zigler MC, Yoshizawa
M, Baylis C, Seals DR. Sodium
nitrite treatment restores vascular endothelial function in old mice with
CKD. FASEB J March 29, 2012
26:865.17
Sasser J, Akinsiku
O, Moningka N, Jezewski K,
LeBlanc A, Kang L, Sindler A, Muller-Delp J,
Baylis C. No sexual dimorphism in
development of kidney damage in the aging Fischer-344 (F344) rat kidney. Submitted to APS Conference on Gender
Disparities in Physiology of Cardiovascular Disease, Oct 2011.
Sindler AL, Howell KL, Zigler ML, LaRocca TJ, Fleenor BS, Calvert JW, Lefer
DJ, Seals DR. Nitrite supplementation improves age-associated vascular
endothelial function and arterial markers of mitochondrial function. Nitric Oxide Volume 24, Supplement 1, May 2011, Page S40
Sindler AL, Marvi NK, Claassen
N, Calvert JW, Lefer DJ, Seals DR. Nitrite supplementation reverses large
elastic artery stiffening with aging: potential role of arterial advanced
glycation end-products. Nitric Oxide Volume 24, Supplement 1, May 2011, Page S27
Sindler AL, Fleenor BS, Zigler ML, Marshall
KD, Howell KL, Seals DR.
Superoxide-lowering therapy with TEMPOL reverses age-associated large
elastic artery stiffening and endothelial dysfunction in mice. FASEB J March
17, 2011 25:821.10
Howell, KL, Fleenor BS, Zigler ML,
Yoshizawa M, Marziaz M,
Seals DR, Sindler AL.
Curcumin improves large elastic artery stiffness and reverses superoxide
suppression of nitric oxide-mediated vascular endothelial function in old mice.
FASEB J March 17, 2011 25:lb453
Fleenor BS, Sindler AL, Marvi
NK, Claassen N, Calvert JW, Lefer
DL, Seals DR. Sodium nitrite
treatment de-stiffens large elastic arteries in old mice: modulation of advanced glycation end-products. FASEB J March 17, 2011 25:641.9
Fleenor BS, Sindler AL, Marshall KD, Sneider H, Marvi N, Esheverria C, Seals DR. Direct evidence for
superoxide signaling in large elastic artery stiffening with aging in mice.
FASEB J March 17, 2011 25:821.33
Henson GD, LaRocca TJ, Sindler
AL, Fleenor BS, Seals DR.
Autophagy-enhancing treatment reverses age-associated large elastic
artery stiffening and modulates arterial superoxide production, inflammation
and collagen I. FASEB J March 17, 2011 25:lb466
LaRocca TJ, Henson GD, Sindler AL,
Seals DR. Autophagy-enhancing
therapy reduces oxidative stress and restores vascular endothelial function in
old mice. FASEB J March 17, 2011 25:lb452
Sindler AL, Calver JW,
Fleenor BS, Zigler ML, Lefer
DJ, Seals DR. Nitrite supplementation reverses vascular endothelial dysfunction
in old mice via improved nitric oxide bioavailability FASEB J. 2010 24:1039.6
Calvert JW, Elston
M, Sindler AL, Gundewar S, Grinsfelder
DB, Aragon JP, Seals DR, Lefer DJ. The Generation and Storage of
Nitric Oxide Metabolites During Exercise Training Contributes to
Exercise-Mediated Cardioprotection J. Am. Coll.
Cardiol.2010;55;A116.E1081
Moningka NC,
Sindler AL, Muller-Delp J, Baylis C. Twelve
Weeks of Treadmill Exercise Accelerates Age-Dependent Kidney Disease in the
Fisher 344 (F344) Male Rat. J Am Soc Nephrol 20: 2009 SA-PO2229
Sindler AL, Delp MD,
Reyes R, Wu G, Muller-Delp JM. Effect
of aging and exercise training on eNOS uncoupling and O2-
signaling in skeletal muscle arterioles. FASEB J. 2009 23:608.12.
Sindler AL, Reyes R, Muller-Delp
J. Oxidant Stress is Required for
Endothelium-Dependent Dilation in Skeletal Muscle Arterioles. The Physiologist Dec 2008 51:p 38.
Morgan SM, Kang LS, Sindler
AL, Kim SJ, Muller-Delp JM. Voltage-gated
Potassium Channel Regulation of Myogenic Activity Increases with Age in Soleus
Muscle Arterioles. Microcirculation Jun 2007, 14; Issue 4/5, p547, VR-44.
Sindler AL, Kang LS, Dominguez J,
Reyes R, Muller-Delp, JM. Effects of Tempol
on Endothelial-Dependent
Vasodilation in Soleus Muscle Arterioles in Response to Age and
Exercise Training. FASEB J 2007,
21:lb462
Sindler AL, Morgan SM, Reyes R, Peterson J,
Frisbee J, Muller-Delp JM, Bryner
R, Hileman SM. Chronic Exercise Training Increases
Insulin Sensitivity in Obese Zucker Rats Potentially
Via Hypothalamic Adiponectin Receptor 1.
Medicine and Science in Sports and Exercise 2006.
38(11): p. Suppl 1: S39.
Funding
R21-HL107105; NIH/NHLBI; 7/2011-6/2013; Clinical Translation
of Nitrite Therapy to Treat Arterial Aging in Humans; Co-Investigator
(Seals, PI)
NIH/Intervention Testing Program; ÒSodium nitrite to
increase longevity in miceÓ
Co-PI: Sindler,
AL (PI: Seals, DR) Agency: National Institute on Aging
University
of Colorado Denver Aging Training Grant (T32) recipient. Role of Dietary
Nitrite Supplementation on Reversing Arterial Aging. 5/01/10-5/01/12
Awards
APS Cardiovascular Section Research
Recognition Award, 2011.
Approaching the Clinic: Nitrite and Nitrate Pathophysiology and Therapy
Conference Presentation Award, 2011.
Professional Affiliations
American Association
for the Advancement of Science
American College of Sports Medicine
American Physiological Society
