Methods Offered (LC/TOF-MS & LC/MS-MS)

• We perform a large-scale screening analysis for 100 pesticides and 50 pharmaceuticals using Accurate Mass Spectrometry (LC/TOF-MS).  This methods allows us to characterize the sample (wastewater, surface water, groundwater and drinking water) for the identification of potential emerging contaminants. 

Click here for a list of LOD's for pesticides: TOF Table Pesticides.

Click here for a list of LOD's for pharmaceuticals: TOF Table Pharmaceuticals.

• We develop custom low-level concentration methods using LC/MS-MS for the detection of pesticides and pharmaceuticals at low ng/L level (examples: carbamazepine at 0.5 ng/L, meprobamate at 1 ng/L, atrazine at 0.2 ng/L, diphenhydramine at 1 ng/L, etc...).  See Table below for approximate LOD's (these will vary depending on the total number of analytes included in the method). 

  Method reporting limits based on a pre-concentration of 100 mL water sample and LC/MS-MS:

   

  CEMS QqQ Method for Pharmaceutical Suite
  Analyte	Number of MRM transitions	Stable Isotope	Analysis Mode	MRL (ng/L)
  1,7-Dimethylxanthine	2		Positive	10
  Acetaminophen	2	x	Positive	5
  Albuterol	2		Positive	5
  Atenolol	2		Positive	5
  Azithromycin	2		Positive	30
  Bisphenol A	2		Negative	10
  Bupropion	2		Positive	10
  Caffeine	2	x	Positive	5
  Carbamazepine	2	x	Positive	1
  Cimetidine	2		Positive	5
  Ciprofloxacin	2	x	Positive	10
  Clarithromycin	2		Positive	5
  Codeine	2		Positive	5
  Cotinine	2	x	Positive	5
  Dehydronifedipine	2		Positive	1
  Diclofenac	2		Positive	10
  Digoxigenin	2		Positive	5
  Diltiazem	2		Positive	1
  Diphenhydramine	2		Positive	1
  Enrofloxacin	2		Positive	5
  Erythromycin	2	x	Positive	5
  Flumequine	2		Positive	5
  Fluoxetine	2	x	Positive	5
  Gemfibrozil	1	x	Negative	10
  Ibuprofen	1	x	Negative	50
  Lincomycin	2		Positive	5
  Meprobamate	2		Positive	1
  Metformin	2		Positive	10
  Miconazole	2		Positive	10
  Naproxen	2	x	Negative	10
  Oxolinic Acid	2		Positive	5
  Ranitidine	2		Positive	10
  Roxithromycin	2		Positive	5
  Sulfachloropyridazine	2		Positive	5
  Sulfadiazine	2		Positive	5
  Sulfadimethoxine	2		Positive	1
  Sulfamerazine	2		Positive	1
  Sulfamethazine	2		Positive	5
  Sulfamethizole	2		Positive	5
  Sulfamethoxazole	2	x	Positive	5
  Sulfanilamide	2		Positive	20
  Sulfathiazole	2		Positive	5
  Thiabendazole	2		Positive	5
  Triclocarban	2	x	Negative	5
  Triclosan (?)	2		Negative
  Trimethoprim	2	x	Positive	5
  Tylosin	2		Positive	30
  Viginiamycin	2		Positive	5
  Warfarin	2		Negative	5

  Contact us for custom method development (michael.thurman@colorado.edu).